Question
Posted on: March 6 2013Chloramphenicol 1% 1 litre for decubitus wound.
Answer
REPLY
- Chloramphenicol has a solubility in water 1 to 400. So 1% becomes what much! The highest concentration I find in preparations is 0.5%. To prepare this solution, an artificial grip should be applied, which consists of the addition of borax, which increases the solubility in water of chloramphenicol.
- as sterile as possible does not exist. Sterile is an absolute concept.
We can use the formula of the FNA for eye drops with omission of the preservative:
R/5g chloramphenicol 15 g Boric Acid 3 G Borax Water for injection up to 1000 ml
If we use the most certain sterilization method namely sterilizing at 100 ° C (flowing water vapour) for 30 minutes in the final container, then the preparation method becomes quite simple. We provide an excess of 5%. Given the patient needs about 100 ml per 2 days for the cleansing of the wound, we divide the solution of one litre over flapullen of 100 ml.
Preparation method In a tarred beaker drilling acid and borax dissolve under heating in 900 ml boiling water for injection; Bring the temperature to 60 ° C and dissolve chloramphenicol at this temperature. Allow to cool and then replenish the solution with water for injections up to 1000 g. Filter this solution particle free by means of a membrane filtration (1 m m) and eventually divide over 10 pre-sterilised flapules of 100 ml. After closing the flapules eventually sterilize using the method of Deussen.