Question
Posted on: February 26 2018Dapsone in a cream process?
This is a specialty on the market in the USA, but we do not find the excipients of the cream back.
Is there a preferred cream base in which dapsone can be processed?
Answer
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Each gram of ACZONE Gel, 7.5%, contains 75 mg or dapsone, USP, in a gel or diethylene glycol monoethyl ether, methylparaben, acrylamide/sodium acryloyldimethyl taurate copolymer, Isohexadecane, Polysorbate 80, and purified water. Several of these ingredients are not available for the pharmacy. Given the solubility of dapsone in ethanol, it may be appropriate to try the water-free carbomb gel of the TMF. I note that in the composition of the Aczone gel a absorption promoter is used namely diethylene glycol monoethyl ether. Also this product is not available. But one might consider using 10% DMSO.