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Question

Posted on: September 12 2015

Dark discoloration of an O/W cream with Metronidazole

The composition is worded as follows: Metronidazole 0.6 g; Salicylic acid 0.9 g; Sulpho resorcinol 0.9 g; Sulfur Praecip. 0.9 g; Cetostearyl alcohol emulsif type B 1.5 g; Sesame oil 1.5 g and Aqua Conserv TMF AD 30 g

Answer

It is known that certain raw materials as EMULG; Cetostearyl alcohol contain impurities. As the first products that are sensitive to that, I would designate salicylic acid and Sulpho resorcinol. Under the influence of iron ions, salicylic acid is purple-dark purple...... But salicylic acid comes in so many creams and discoloration is sometimes signalled. But here we also have metronidazole, which we cannot and cannot exclude. Therefore, a preview should be done   with a cream without metronidazole. Discolours that too? Although every product can have an influence, I now assume that sulfur does not play a role. If we want to exclude this then more splits have to be made.. Maybe postpone this again.