Question
Posted on: March 6 2013How to prepare next cream: 15g liquid Carbonis detergent 15g chlorbutolhydrate 15g Salicylic acid 800mg Zinc sulfate 480mg methylprednisolone 480mg dexamethasone
120mg betamethasonedipropionate
51g cetyl alcohol
63g White Vaseline
40g glycerol
21g Tween 80
ad 300g aqua < BR/> If we only make the ointment base, this does not give any problems. LCD, salicylic acid and chlorbutolhydrate in lower concentrations are also found to succeed and without chlorbutol it gives no problem at all.
The ointment does not discerner immediately, when mixing everything seems to be homogeneous and after ten minutes she goes piece. Even the chlorbutol dissolving in the still liquid petroleum jelly does not help.
51g cetyl alcohol
63g White Vaseline
40g glycerol
21g Tween 80
ad 300g aqua < BR/> If we only make the ointment base, this does not give any problems. LCD, salicylic acid and chlorbutolhydrate in lower concentrations are also found to succeed and without chlorbutol it gives no problem at all.
The ointment does not discerner immediately, when mixing everything seems to be homogeneous and after ten minutes she goes piece. Even the chlorbutol dissolving in the still liquid petroleum jelly does not help.
Answer
A first important remark is the occurrence in this composition of a number of corticosteroids, which are not common in dermatology. I suspect that this has something to do with the regulation of the R.I.Z.I.V. secondly, the high concentration of chlorbutol, which gives rise to a melting point reduction.
In Most creams comes a mixture of liquid paraffin and petroleum jelly. So I would take 31.5 g of them. In the liquid paraffin you can dissolve the chlorbutol and the LCD in the water phase. If this proves insufficient, I suggest adding 5 g of white wax in order to compensate for the melting point reduction.
The remaining powders are mixed and then rubbed with the fully cooled CR è me. ZnSO4 solves it in the external phase.. Very important is also the homogeneity of the Cortico & #039; s in the CR è me; You should work with dilutions 1 in 10 and for Betamethasone 1 on 50!
In Most creams comes a mixture of liquid paraffin and petroleum jelly. So I would take 31.5 g of them. In the liquid paraffin you can dissolve the chlorbutol and the LCD in the water phase. If this proves insufficient, I suggest adding 5 g of white wax in order to compensate for the melting point reduction.
The remaining powders are mixed and then rubbed with the fully cooled CR è me. ZnSO4 solves it in the external phase.. Very important is also the homogeneity of the Cortico & #039; s in the CR è me; You should work with dilutions 1 in 10 and for Betamethasone 1 on 50!