Is it possible to supply a sterile 0.5% solution of metronidazole in water to replace the Flagyl IV solution now used and for wound rinse?

the Flagyl solution has as composition: Metronidazole 500mg, disodium phosphate dodecahydrate, citric acid monohydrate, sodium chloride and water for injection AD 100ml solution. It is packaged in a translucent infusion pouch.

I suggest as a compound: Metronidazole 5.0 g, NaH2PO4 Anh. 476.0 mg, citric acid anh. 229.0 mg, NaCl 7.9 g and water for injections up to 1l.

if the correct (in the case of crystalline water) Ingredi ë Nten are available, the necessary conversions shall be be made.

THIS SOLUTION MUST POSSESS a pH OF 5! Please check.

Given that we have to do with an open wound, the solution should be delivered sterile. A quantity of 300ml seems acceptable, given that we do not add a preservative. Something we find in certain formulations, but in this case it is better to avoid preservatives. In terms of sterilization, different methods of working are found. Personally, I would prefer car clubs at 121 ° C for 20 minutes. An accelerated cooling (caution for glass breakage! So first let cool to +/-90 ° C) is desired as well as an overdose of 5% to compensate for a slight degradation of 2 à 3%.

Water for injections should be used for the preparation of the solution, which is filtered free of particles for the car clubs. This can be on a 0.22 membrane filter, which does not need to be sterilized.

as packaging we make use of a red-brown bottle for external use. The solution should be protected from light. Packing in a cardboard box is another precaution against not storing the bottle in the dark.