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Question

Posted on: April 8 2014

Prevent green discoloration of cream with salicylic acid

R/Clobetasoldiprop. 25mg Chlorhex. Gluc. 20% OPL. 1, 25g Salicylic Acid 2g CETOMACROGL Creme ad 50g We used buffered Cetomacrogol cream for the sake of the presence of salicylic acid, but apparently this is not compatible with Chlorhexidine What basis do we use in order to obtain a stable preparation with salicylic acid and chlorhexidine?

Answer

You apparently set two questions.

The first question about the discoloration should most likely be linked to salicylic acid, a product that easily discolours under the influence of metals, which may well prevent it from being in minimal quantities. Thus, best Na2EDTA can be added in a concentration of 0.1%.  

Or salicylic acid is incompatible with chlorhexidinedigluconate, I cannot exclude it with certainty. I do know that salicylic acid is incompatible with PEG-containing compounds like cetomacrogol. So is a cream based on Laurylsulaat a better choice but in this recipe we come from the drop   in the rain there we then get to deal with the incompatibility Chlorhexid + with lauryl sulfate. There is the possibility that the lauryl sulfate present does not react all the way so that sufficient O/W emulsifier remains for the formation of the emulsion.   This is not the case then NaCl (+/-30 mg) can be added, so that the digluconnat converts to the insoluble dihydrochloride is an option to neutralize the pernicious effect of chlorhexidine. Chlorhexidine Dihydrochloride is a salt that is used in antiseptic creams.  

We can therefore recommend: 1. Add EDTA and check that the discoloration is left out; 2. Add NaCl and use a cream based on lauryl sulfate like e.g. Beeler basis.