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Question

Posted on: March 18 2017

At the request of a dermatologist: Clobetasol propionate in a nail polish? And in what concentration?

Answer

Clobetasolpropionate to 8% seems to give the best result

http://www.scielo.br/scielo.php?pid=S0365-05962012000200003&script=sci_arttext&tlng=pt

As Exipiens is in Belgium little choice. The first possibility is Coll Odium, the second cellulosacetophate solution.

Following possibility was found: collodion and ethanol AA 1 part. But the solubility in ethanol is only 20 mg/ml. On the other hand, Clobetasol propionate is described as soluble in acetone and DMSO. This means 33 mg to 100 mg per ml. For DMSO is specified 93 mg/ml; No value could be found for acetone. My   preference goes to DMSO because this is solvent as a absorption promoter since.