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Question

Posted on: November 15 2017

Venlafaxine in syrup: possible?

Since this is always a retardform, I wonder whether it is possible? It is for a stomapatient not picking up venlafaxine. The tablets or capsules (and spheres when opening the capsule) are directly in the stoma. As a result, she even starts to get withdrawal symptoms.

Answer

Tablet composition  

core:

Mannitol (E421)

Povidon K-90 Macrogol 400 Microcrystalline cellulose colloidal anhydrous silicon dioxide magnesium stearate

Shell: C Elluloseacetate Macrogol 400 Hypromellose Lactose monohydrate Titanium dioxide (E171) Triacetine  

The retard effect is realized by a semipermeable coating, which becomes more porous as the content of the nucleus decreases.  

you will have to crush the tablets and because of the coating this is slightly harder. Personally, I would try to crush the tablets roughly in a mortar and then grind them with an elctric coffee grinder hoping to get the coating fine too. The powder mixture is recommended to be sieving and to remove the residue from the coating.  

In   The literature I find a suspension with 75 mg/5 ml  

You can use as Excipient venlaflaxine 1.5 g   ; sorbitol 40 g; Veegum 1 G; Xanthan gum 100 mg; Tween 80 150 mg; After saccharinate 100 mg; Mint water based on Aqua Conservans up to 100 ml

There are some excipients in the core of the tablet, which can give a certain viscosity, I cannot pronounce on the viscosity obtained and   might be the Addition of livestock gum and xanthan gum unnecessary. Practice will have to show this out. If you have insufficient viscosity, the thickening agent can still be added at the end.