We are asked to make a cream on the basis of the Aacifemine ovules, because it is currently lacking. Is this possible?

In my opinion, this will be difficult given the pessaries contain only 0, 5mg estriol per ovule. For 15g CR è me we need 30 pessaries. These can then form the internal phase of our CR è me but in order to obtain an O/W cr è me, water must also be added. All this makes it very difficult to obtain a dosage of 1mg estriol per G. Therefore, I suggest going out of the tablets, which contain 2mg estriol per tablet. The required number is first finely made in the mortar and then crushed to a very fine powder in an electric coffee grinder. The obtained powder is sieved. This powder can be further conceived in a CR è me base suitable for vaginal use or in a carbomeer gel.