Why Menadian sodium bisulfite with mannitol? -Should a trituration always be taken by 5% overdose?

On question 1 I give you the opinion of Prof. Delattre, president of the TMF Committee.  

dance the familles formulas de gélules, on a le choix: l'excipient diluant a ou l'excipient diluant B. Je préfère l'excipient diluant b qui s'écoule mieux que l'excipient diluant a et est plus facile à triturer avec la plupart des Substances actives dans le mortier, principalement avec les substances actives faiblement dosées. Inconvénient sur le plan financier: you crois que le mannitol at plus cher que le lactose. Dans le cas des gélules de vitamin K qui sont faiblement dosées, le choix de l'excipient diluant B est plus judicieux même s'il n'y a pas d'incompatibilité entre le lactose et la ménadione bisulfite Na. as far as other e vitamins are concerned, I believe that the TMF publishes some formulas. on question 2 I have to answer that whether or not overdosing is strongly determined by BV the content of the capsules that are prepared. If the content < 10 mg per capsule of dance is an overdose desired. The characteristics of the active ingredient with which a dilution is prepared, determine to a large extent the necessity of overdosing together with the degree of dilution. In certain raw materials such as corticosteroids, non-acceptable losses to active substance were identified. It is advised to prepare these dilutions with certain precautions like e.g. the use of a smooth mortar. But do you think that a smooth mortar remains smooth throughout   his entire life?