Question
Posted on: March 6 2013By which product can triethanolamine, which is no longer reimbursed by the RIZIV, be replaced? And what quantity do we use? Urea 20g Betamethasone propionate 60mg
Sweet Almond oil 16g
glyceryl monostearate 8g
triethanolamine 6
Rosewater 85g
Water for preservation 85g < BR/>
glyceryl monostearate 8g
triethanolamine 6
Rosewater 85g
Water for preservation 85g < BR/>
Answer
This composition is peculiar to me. She appears to be a stearaatcreme but with a minimum of fatty acids, given glycerinemonostearate contains only leftovers of fatty acids.
The amount of water and the presence of Triethanolamine suggest that the prescriber wants an O/W lotio.
If you make the preparation with Monostearine PB V you obtain an O/W given the presence of soaps in Monostearine. More likely is that you will use Monostearine Ph Eur in which no soaps occur and that is therefore a W/O emulsifier.
If we assume that Monostearine PB V contains 10% soap, we could divide 8 g of glyceryl monostearate into 7.2 g of glyceryl monostearate and 0.8 g of ammonium stearate. The latter is prepared from stearic acid and ammonia. Ammonia is preferable to Triethanolamine because the latter is removed from the lists of the RIZIV.
but the aqueous phase of the emulsion thus receives an of PH, which is detrimental to Betamethasone propionate. Therefore, I suggest replacing 0.8 g of ammoniastearate with 0.8 g Nalauryl Sulfate, which gives a neutral pH in water. Ideal would then be to use the phosphate buffer as in some Corticostero ï decr è Knife is common in the TMF.
The amount of water and the presence of Triethanolamine suggest that the prescriber wants an O/W lotio.
If you make the preparation with Monostearine PB V you obtain an O/W given the presence of soaps in Monostearine. More likely is that you will use Monostearine Ph Eur in which no soaps occur and that is therefore a W/O emulsifier.
If we assume that Monostearine PB V contains 10% soap, we could divide 8 g of glyceryl monostearate into 7.2 g of glyceryl monostearate and 0.8 g of ammonium stearate. The latter is prepared from stearic acid and ammonia. Ammonia is preferable to Triethanolamine because the latter is removed from the lists of the RIZIV.
but the aqueous phase of the emulsion thus receives an of PH, which is detrimental to Betamethasone propionate. Therefore, I suggest replacing 0.8 g of ammoniastearate with 0.8 g Nalauryl Sulfate, which gives a neutral pH in water. Ideal would then be to use the phosphate buffer as in some Corticostero ï decr è Knife is common in the TMF.
Try this proposal on a quarter of the amount without betamethasone to check that the viscosity and stability are good. If not then you can add some grams of glycerinemonostearate.