Vraag
Gepost op: 25 februari 2019Elocom en Nizoral verenigbaar met erythromycine ??
Antwoord
Elke gram lipofiele Elocom crème of zalf bevat 1 mg mometasonfuroaat.
Daarnaast geldt het volgende mbt de stabiliteit van mometasone furoate (MF). The stability of MF decreased with increasing pH (>4) and decreasing ionic strength in aqueous media. The chemical stability of MF in aqueous systems was significantly dependent on pH. MF appeared to be stable at pH < 4 (daarm toevoeging van fosforzuur) but degraded to four products at higher pH. The turnover of MF and its products appears to be catalyzed by the hydroxide ion. The pH dependence of these reactions should be considered, when formulating or extemporaneously compounding MF formulations. An optimal pH of stability was below pH 4. The changes in pH, however, do not appear to be the only factor of importance, since an increase in ionic strength and buffer concentration displayed a stabilizing effect on this glucocorticoid in the buffers tested. Trace metal ions are unlikely to be involved in degradation of MF in aqueous solution