0.6% Nipagine in an O/W cream urea 1% cetyl Alcohol 16% sesame oil 20% glyerol 20% nipagine 0.6% after lauryl sulfate 1% water ad 100g

The added nipagine will divide into this CR è me between the water and the oil phase. The solubility at KT for Nipagine in water is 1 on 400 or 0.6 in 240. For glycerin, the value is 1 on 60 and for a vegetable oil +/-1 on 200.

We can use the formula log S (T) = V (w) log s (w) + V (g) log s (g) + V (o) log S (O)

log s (w) = 0.4; log S (g) = 1.2; log S (o) = 0.7

This indicates S (T) 4.17 mg/ml or 417MG at 100ml.

so I would suggest , reduce the amount of nipagine to 400 mg.