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Question

Posted on: March 6 2013

The authors Wolf and Sürüp mention ' Bei pH6 erfolgt eine Inaktivierung von Erythromycin innerhalb von 1-3 Stunden '. The Cetomacrogol cream buffered at pH 5 would therefore not be suitable

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Answer

I have to bite these authors because the optimal pH for maximum stability of erythromycin is located near 8. A stability of 2 months is guaranteed by the TMF provided a slight overdose.