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Question

Posted on: October 27 2014

Geomycin cream is no longer available. Is this a loco?

An elderly lady has a leg wound and the doctor prescribes Geomycin creme 0.1%. But this product is out of the trade, only the vials of gentamcine 80mg/80ml are available. The most feasible seems to me is to prepare a gel here (0.1%). Can I prepare it both with carbomeer, or MC or HPC or... Which excipients should I take into account? Is it sufficient to disinact my mortar and pestle with disinfectant alcohol to work as germ-free as possible?

Answer

Given the concentration of the solution you have = 1mg/ml You do not have a play area. As a gelvormer you can use Hydroxypropylcellulose (Klucel GF), which you should dissolve in a concentration of 5% in the   gentamycin solution. Adding an intermediate fabric to avoid clumping is not included. You would need at least 5 G glycerin and you already have a concentration reduction by solving 5 g HPC. But after a certain wait time, the HPC,   slowly   added stirring well to the gentamycin solution, will   probably solve it. Meanwhile, cover the cooking vessel well!  

more possibilities offer for the preparation of this gel when one uses the Gentamycin solution 3mg/ml seen than per 100 g gel only 34 ml of gentamycin solution is needed. Over 66   ML remains for the preparation of a gel, which can therefore be sterilized separately using heat.   I n a second stage is diluted with the gentamycin solution  .  

In both cases, the gel is filled in a sterilized tube. Sterilization of the tube is possible by heat, after wrapping the tube in parchment paper. A boiling pressure pan can serve as an alternative to the classic autoclave. After sterilization, the wrapped tube is dried. The cap of the tube is treated with alcohol 70 °  

The shelf life of the gel is limited to 1 month under preservation in the refrigerator.