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Question

Posted on: March 6 2013

How do I best make the following suppos: ESS Thymus vulgaris 20 mg ess Pinus sylvestris 20 mg ess Eucalyptus globulus 20 mg ess Rosmarinus 20 mg extr Bellad 3.5 mg guaifenesin

6 mg
Prometazine 3.5 mg
codeine phosphate 2.5 mg < BR/> for 20 Suppo I add 100 mg aerosil myself, and I use as a base Cutina GMS 1.4 G, witepsol 1 G and Suppocire ASX 18 G. It all succeeds, but there are & #039; cracks & #039; in the Suppo & #039; s.

Answer

Two problems occur in these suppositories:
  1. The processing of the layer of dosed products and
  2. The melting point bearing caused by the volatile Oli ë N and Guiafenesine, which presumably also dissolves in the suppository base.
For the 1. I prefer the mixture of extr Bellad with promethazineHCl and code ï nephosphate to dilute with powdered lactose 500 mg per suppository. Aerosil is known for its adsorption properties and this is not beneficial for the dispensing of the medicinal products.

for 2. I calculate a melting point reduction of 1.5 ° C so a mass with SMTP 36.5 à 37 ° C. Suppocire AS2X seems OK.

the necessity of Cutina GMS I do not see unless water-alcohol-glycerin was added to EXTR. Bellad. To solve, which is not recommended. In addition, when using AS2X, GMS is superfluous, given "letter X indicates the presence of a non-ionic emulsifying additive that enables incorporation of water or alcoholic extracts or solutions" .