Question
Posted on: March 6 2013How to process chloralhydrate 150mg in PEG-suppository base?
Given only the PEG 400 and 4000 to be obtained, I made a mixture of these 2. At a ratio of 2 to 3 I obtained a suppository that was still just fixed enough. When the amount of PEG 400 was increased, the suppo was not hard enough anymore. I determined the melting point of the suppo. This amounted to (37 à 38 ° C. At a temp of 37 ° C the Suppo melted in 10 min. Can this suppo (which will also dissolve in rectal fluid) be used in an epileptic attack that lasts only a 5tal min? The ideal melting point would be around 35 ° C. How can I lower the melting point without adding PEG 400?
Answer
I suppose you have already flushed out the question box for Chloralhydrate suppositories. Not that there is the solution to find your problem immediately but still interesting to read. Indeed most questions deal with larger concentrations of chloral hydrate.
I thought that now even PEG 1500/300 is available? Maybe it pays to try this base. Are the suppositories too soft then it could be added in small quantity: ADEPs solidus, cetyl alcohol. Maybe adding a small amount of water to YOUR formula also gives a speeding up of the melting process?
But if it has to work so quickly then Rectioles will offer a much better solution. This exists for diazepam and is discussed on the question box.
Clysmaflacon 3 ml of Pontos (10pcs), CNK 1760-388 can be obtained from Febelco. They feature a detachable top.