Mixed with Elocom lotion, neomycin sulfate causes a precipitate in the form of a cake

Elocom 0.1% solution for cutaneous use:

-  The active ingredient is mometasonfuroate 1 mg/g.- Other ingredients are:     Isopropyl alcohol, hydroxypropylcellulose, propylene glycol, sodium dihydrogeenphosphate dihydrate, diluted Phosphoric acid, purified water.   The solubility of neomycin sulfate in alcohols is: in ethanol 0.095 and isopropanol 0.082 mg/ml

The use of Hydroxypropylcellulose indicates a high level of isopropanol in Elocom lotion. So..........................

should   Mometasonfuroate be available   as raw material, we would proceed to the preparation of an aqueous suspension, which admittedly does not exhibit the same therapeutic activity as Elocom, since the latter has dissolved the Cortico in the isopropanol propylene glycol water mixture.   In This aqueous medium, neomycin sulfate is soluble if we use a non-ionogenic swelling compound. Here, therefore, the only solution in addition to the Elocom lotion remains to deliver an aqueous solution with the prescribed concentration of neomycin sulfate. In turn, the patient uses one or the other specimen