Question
Posted on: March 6 2013From palliative care we get a prescription for a pharmacy preparation: Depakine Chrono 500 f suppo n ° I, DT 60
The Galenic question is double:
- Can we process such a quantity of powder (more than half a gram per suppo) in an acceptable way in suppositories?
- can the controlled exemption of the Chrono tablets be preserved when rubbing?
Answer
In addition to Depakine Chrono 500 50 tablets, the enteric coated 500mg/100 tablets also exist. For starters, 1 box of Chrono is insufficient for this preparation. To be able to process the tablets in suppositories they must be finely rubbed and therefore the controlled exemption is completely or partially lost. In any case she gets unreliable. Personally, I would appeal to the enteric encased. After all, 1 packaging is sufficient for this preparation and secondly there may be the possibility to cut the enteric film lightly with a razor blade and peel it off. So we are from all that rubbish largely from. Then we grind the tablets in a coffee grinder. If we cannot peel off the film, we grind the tablets on their whole.
processing half a gram of powder mass in suppository Mass for BV suppositories of 2g can not be a problem.
processing half a gram of powder mass in suppository Mass for BV suppositories of 2g can not be a problem.
/question box/0505.gif & #039; BORDER = 0 >