Please provide a triple bleaching cream therapy containg hydrocortisone (or any low-potency corticosteroid, hydroquinone, and Retin-A. How long will this cream be stable?

I can propose the following formula:

Hydroquinone 2.5 G Hydrocortisone acetate 500 mg Tretinoine (Retinoic acid) 25 mg Lactic acid 500 mg Glycerin 5 G Ascorbic acid 500 mg Disodium EDTA 75 mg White Beeswax 3 G Cetaceum 2.5 G Cetiol 15.5 g Span 80 1 G Arlacel C 4 G Freshly boiled water AD 50 g

COMMENTS

I cannot give stability data for this cream. However Several precautions (antioxidant, pH) are tasks to make the preparation as stable as possible. But I would still advice to store the cream in the fridge! And not to use it longer than two months. Might I Find more information on this item I shall inform you. Normally A stronger corticosteroid is added as for example Triamcinolone acetonide. But this would make a prescription obligatory at least in my country. I hope this composition will give satisfaction? The cream is of the W/O type. Probably to have a of release and to protect in some way some ingredients for oxidation.