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Question

Posted on: March 6 2013

Problems with sagging powders in Suppomassa if they are molded: Belladonna dry extract 5mg coffe ï ne 100mg ergotaminetartraat 2mg cyclinzine HCl 50mg

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Answer

I suspect primarily coffe ï NE and cyclizine as causes of this problem. Coffe ï NE has the tendency of aggloming under the influence of moisture and the formed agglomerates are harsh. Grind the powder mixture using a coffee grinder sieve on a sieve 300 to verify that everything is fine and mix again slightly after this operation.
of course, the way in which powder mass and melted suppository mass are mixed also has an influence along with the temperature at which the form is poured. Mix frequently the contents of the Zetpilpan when pouring.