Question
Posted on: November 15 2017Venlafaxine in syrup: possible?
Answer
Tablet composition
core:
Mannitol (E421)
Povidon K-90 Macrogol 400 Microcrystalline cellulose colloidal anhydrous silicon dioxide magnesium stearate
Shell: C Elluloseacetate Macrogol 400 Hypromellose Lactose monohydrate Titanium dioxide (E171) Triacetine
The retard effect is realized by a semipermeable coating, which becomes more porous as the content of the nucleus decreases.
you will have to crush the tablets and because of the coating this is slightly harder. Personally, I would try to crush the tablets roughly in a mortar and then grind them with an elctric coffee grinder hoping to get the coating fine too. The powder mixture is recommended to be sieving and to remove the residue from the coating.
In The literature I find a suspension with 75 mg/5 ml
You can use as Excipient venlaflaxine 1.5 g ; sorbitol 40 g; Veegum 1 G; Xanthan gum 100 mg; Tween 80 150 mg; After saccharinate 100 mg; Mint water based on Aqua Conservans up to 100 ml
There are some excipients in the core of the tablet, which can give a certain viscosity, I cannot pronounce on the viscosity obtained and might be the Addition of livestock gum and xanthan gum unnecessary. Practice will have to show this out. If you have insufficient viscosity, the thickening agent can still be added at the end.