Chloramphenicol 1% 1 litre for decubitus wound.

REPLY

1. Chloramphenicol has a solubility in water 1 to 400. So 1% becomes what much! The highest concentration I find in preparations is 0.5%. To prepare this solution, an artificial grip should be applied, which consists of the addition of borax, which increases the solubility in water of chloramphenicol.
2. as sterile as possible does not exist. Sterile is an absolute concept.

We can use the formula of the FNA for eye drops with omission of the preservative:

R/5g chloramphenicol 15 g Boric Acid 3 G Borax Water for injection up to 1000 ml

If we use the most certain sterilization method namely sterilizing at 100 ° C (flowing water vapour) for 30 minutes in the final container, then the preparation method becomes quite simple. We provide an excess of 5%. Given the patient needs about 100 ml per 2 days for the cleansing of the wound, we divide the solution of one litre over flapullen of 100 ml.

Preparation method In a tarred beaker drilling acid and borax dissolve under heating in 900 ml boiling water for injection; Bring the temperature to 60 ° C and dissolve chloramphenicol at this temperature. Allow to cool and then replenish the solution with water for injections up to 1000 g. Filter this solution particle free by means of a membrane filtration (1 m m) and eventually divide over 10 pre-sterilised flapules of 100 ml. After closing the flapules eventually sterilize using the method of Deussen.