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Question

Posted on: March 6 2013

We have problems with the following suspension:

Tetracycline 3 G Precipitated Sulphur 20 g Camphor 5 G Sulpho Resorcinol 10 g Camphor Spiritus 20 g Tragacant 4 G Aqua Dest. AD 300 ml < br/> When the core suspension is diluted with water, a thin liquid containing large grains, which are no longer homogeneous to be mixed, is also not shaken up after good shaking.

Answer

As in a previous question (' How can this be best prepared? '), it is also necessary to add postphosphate to obtain a precipitate of teracycline. It promotes the stability of the tetra and avoids the incompatibility with tragacanth that you have observed. On page 125 of the Galenic formulary, the ratio of 3 disodium phosphate is 12 aq to 4 tetracycline. HCl. I would first mix phosphate, sulfur and tragacant; Then moisten with 200 mg of Tween and Camphor Spiritus in which the remaining camphor is dissolved gradually add.

In addition, Tetra and Sulpho resorcinol are dissolved in 150 ml of water and this solution is slowly poured under good stirring at the mass in the mortar. The suspension is transferred into a measuring cylinder and the mortar is rinsed several times with the remaining water.